Increased Insulin Sensitivity is Not Required for Extension of Healthy Life Span in Mice via Calorie Restriction

The biochemistry surrounding insulin and insulin signaling is very well studied in the context of aging. A number of ways to slow aging in laboratory species involve directly manipulating these signaling pathways. Calorie restriction, like a number of other methods of slowing aging, improves insulin sensitivity, and the consensus in the research community has been that some fraction of the benefits to health and longevity that result from a restricted calorie intake are derived from this change to insulin metabolism. Today’s open access paper provides evidence to suggest, surprisingly, that this is not in fact the case. It is possible to block this part of the calorie restriction response, and the effect on health and longevity is much the same. What, then, are the mechanisms by which

from http://besthealthnews.com/2019/10/increased-insulin-sensitivity-is-not-required-for-extension-of-healthy-life-span-in-mice-via-calorie-restriction/?utm_source=rss&utm_medium=rss&utm_campaign=increased-insulin-sensitivity-is-not-required-for-extension-of-healthy-life-span-in-mice-via-calorie-restriction

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