LANDO Found to be Key to Microglial Clearance of Amyloid-β and Neuroinflammation

The consensus view on the progression of Alzheimer’s disease is that it begins with rising levels of amyloid-β aggregates, misfolded proteins forming solid deposits to disrupt cellular behavior. This increase in amyloid-β might be due to persistent infection, as amyloid-β is an antimicrobial peptide, a part of the innate immune system. It might be due to failing drainage of cerebrospinal fluid, causing all molecular wastes to build up in the brain. There are other possibilities as well, such as progressive failure of the ability of immune cells to clear out amyloid-β. In and of itself this rising level of amyloid-β seems to, at worst, cause mild cognitive impairment via dysfunction of neurons. Unfortunately it also causes microglia and other support cells to

from https://www.fightaging.org/archives/2019/07/lando-found-to-be-key-to-microglial-clearance-of-amyloid-β-and-neuroinflammation/

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